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Did you mean PNPLA2 and life (49 results)?
The ménage à trois of autophagy, lipid droplets and liver disease.
Filali-Mouncef Y, Hunter C, Roccio F, Zagkou S, Dupont N, Primard C, Proikas-Cezanne T, Reggiori F. Filali-Mouncef Y, et al. Autophagy. 2022 Jan;18(1):50-72. doi: 10.1080/15548627.2021.1895658. Epub 2021 Apr 2. Autophagy. 2022. PMID: 33794741 Free PMC article. Review.
Particular attention is paid to the role of macroautophagy and macrolipophagy in relation to the parenchymal and non-parenchymal cells of the liver in NASH, as this disease has been associated with inappropriate lipophagy in various cell types of the liver.Abbreviations: ACAT: ac …
Particular attention is paid to the role of macroautophagy and macrolipophagy in relation to the parenchymal and non-parenchymal cells of th …
Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice.
Wu JW, Preuss C, Wang SP, Yang H, Ji B, Carter GW, Gladdy R, Andelfinger G, Mitchell GA. Wu JW, et al. PLoS Genet. 2017 May 1;13(5):e1006716. doi: 10.1371/journal.pgen.1006716. eCollection 2017 May. PLoS Genet. 2017. PMID: 28459858 Free PMC article.
We generated mice with adipose tissue deficiency of two major enzymes of lipolysis, adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), encoded respectively by Pnpla2 and Lipe. Adipocytes from double adipose knockout (DAKO) mice, deficient in both …
We generated mice with adipose tissue deficiency of two major enzymes of lipolysis, adipose triglyceride lipase (ATGL) and hormone-sensitive …
An Epistatic Interaction between Pnpla2 and Lipe Reveals New Pathways of Adipose Tissue Lipolysis.
Zhang X, Zhang CC, Yang H, Soni KG, Wang SP, Mitchell GA, Wu JW. Zhang X, et al. Cells. 2019 Apr 29;8(5):395. doi: 10.3390/cells8050395. Cells. 2019. PMID: 31035700 Free PMC article.
These results reveal a previously unknown physiological redundancy between ATGL and HSL, a mechanism for the epistatic interaction between Pnpla2 and Lipe. It provides an alternative lipolytic pathway, potentially important in patients with deficient lipolysis....
These results reveal a previously unknown physiological redundancy between ATGL and HSL, a mechanism for the epistatic interaction between …
Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.
Yau WW, Singh BK, Lesmana R, Zhou J, Sinha RA, Wong KA, Wu Y, Bay BH, Sugii S, Sun L, Yen PM. Yau WW, et al. Autophagy. 2019 Jan;15(1):131-150. doi: 10.1080/15548627.2018.1511263. Epub 2018 Sep 13. Autophagy. 2019. PMID: 30209975 Free PMC article.
Abbreviations: ACACA: acetyl-Coenzyme A carboxylase alpha; AMPK: AMP-activated protein kinase; Acsl1: acyl-CoA synthetase long-chain family member 1; ATG5: autophagy related 5; ATG7: autophagy related 7; ATP: adenosine triphosphate; BAT: brown adipose tissue; cKO: conditional kno …
Abbreviations: ACACA: acetyl-Coenzyme A carboxylase alpha; AMPK: AMP-activated protein kinase; Acsl1: acyl-CoA synthetase long-chain family …
Targeting lipophagy in macrophages improves repair in multiple sclerosis.
Haidar M, Loix M, Vanherle S, Dierckx T, Vangansewinkel T, Gervois P, Wolfs E, Lambrichts I, Bogie JFJ, Hendriks JJA. Haidar M, et al. Autophagy. 2022 Nov;18(11):2697-2710. doi: 10.1080/15548627.2022.2047343. Epub 2022 Mar 14. Autophagy. 2022. PMID: 35282773 Free PMC article.
In summary, our results provide a molecular rationale for impaired metabolism of myelin-derived lipids in macrophages, and identify lipophagy induction as a promising treatment strategy to promote remyelination.Abbreviations: Baf: bafilomycin a1; BMDM: bone marrow-derived macroph …
In summary, our results provide a molecular rationale for impaired metabolism of myelin-derived lipids in macrophages, and identify lipophag …
Specific miRNAs are associated with human cancer cachexia in an organ-specific manner.
Krauss T, Heisz S, Honecker J, Prokopchuk O, Martignoni M, Janssen KP, Claussnitzer M, Hauner H, Seeliger C. Krauss T, et al. J Cachexia Sarcopenia Muscle. 2023 Jun;14(3):1381-1394. doi: 10.1002/jcsm.13224. Epub 2023 Apr 6. J Cachexia Sarcopenia Muscle. 2023. PMID: 37021483 Free PMC article.

Knock-down experiments in human visceral preadipocytes revealed an inverse association of miR-424-5p with its predicted target genes LIPE, PNPLA2, MGLL and LPL (P < 0.01). CONCLUSIONS: The identified miRNAs, in particular miR-122-5p, miR-27b-3p, miR-375 and miR-4

…
Knock-down experiments in human visceral preadipocytes revealed an inverse association of miR-424-5p with its predicted target genes LIPE …
Resting skeletal muscle PNPLA2 (ATGL) and CPT1B are associated with peak fat oxidation rates in men and women but do not explain observed sex differences.
Chrzanowski-Smith OJ, Edinburgh RM, Smith E, Thomas MP, Walhin JP, Koumanov F, Williams S, Betts JA, Gonzalez JT. Chrzanowski-Smith OJ, et al. Exp Physiol. 2021 May;106(5):1208-1223. doi: 10.1113/EP089431. Epub 2021 Mar 18. Exp Physiol. 2021. PMID: 33675111 Free article.
Resting adipose tissue and/or skeletal muscle biopsies were obtained to determine the adipose tissue protein content of PLIN1, ABHD5 (CGI-58), LIPE (HSL), PNPLA2 (ATGL), ACSL1, CPT1B and oestrogen receptor alpha (ERalpha) and the skeletal muscle protein content of F …
Resting adipose tissue and/or skeletal muscle biopsies were obtained to determine the adipose tissue protein content of PLIN1, ABHD5 (CGI-58 …
Upregulation of Pnpla2 and Abhd5 and downregulation of G0s2 gene expression in mesenteric white adipose tissue as a potential reason for elevated concentration of circulating NEFA after removal of retroperitoneal, epididymal, and inguinal adipose tissue.
Dettlaff-Pokora A, Sledzinski T, Swierczynski J. Dettlaff-Pokora A, et al. Mol Cell Biochem. 2016 Nov;422(1-2):21-29. doi: 10.1007/s11010-016-2800-4. Epub 2016 Sep 2. Mol Cell Biochem. 2016. PMID: 27590244 Free PMC article.
Reduction of adipose tissue mass resulted in an increase in circulating NEFA concentration, which was associated with (a) an increase in the expressions of Pnpla2 and Abhd5, (b) decrease in G0s2 expression, and (c) upregulation of Lipe expression, all measured on bo …
Reduction of adipose tissue mass resulted in an increase in circulating NEFA concentration, which was associated with (a) an increase in the …
Progesterone-induced down-regulation of hormone sensitive lipase (Lipe) and up-regulation of G0/G1 switch 2 (G0s2) genes expression in inguinal adipose tissue of female rats is reflected by diminished rate of lipolysis.
Stelmanska E, Szrok S, Swierczynski J. Stelmanska E, et al. J Steroid Biochem Mol Biol. 2015 Mar;147:31-9. doi: 10.1016/j.jsbmb.2014.11.017. Epub 2014 Nov 20. J Steroid Biochem Mol Biol. 2015. PMID: 25448749
The aim of this study was to analyze the effect of progesterone on the expression of: (a) Lipe (encoding hormone-sensitive lipase, HSL), (b) Pnpla2 (encoding adipose triglyceride lipase, ATGL), (c) abhydrolase domain containing 5 (Abhd5), and (d) G0/G1 switch 2 (G0s …
The aim of this study was to analyze the effect of progesterone on the expression of: (a) Lipe (encoding hormone-sensitive lipase, HS …
Inborn errors of cytoplasmic triglyceride metabolism.
Wu JW, Yang H, Wang SP, Soni KG, Brunel-Guitton C, Mitchell GA. Wu JW, et al. J Inherit Metab Dis. 2015 Jan;38(1):85-98. doi: 10.1007/s10545-014-9767-7. Epub 2014 Oct 10. J Inherit Metab Dis. 2015. PMID: 25300978 Review.
We discuss known inborn errors of CTGM, including deficiencies of: AGPAT2 (a form of generalized lipodystrophy), LPIN1 (childhood rhabdomyolysis), LPIN2 (an inflammatory condition, Majeed syndrome, described elsewhere in this issue), DGAT1 (protein loosing enteropathy), perilipin …
We discuss known inborn errors of CTGM, including deficiencies of: AGPAT2 (a form of generalized lipodystrophy), LPIN1 (childhood rhabdomyol …
42 results